Engineering Approach
Target Overexpression-Lentivirus
Alternative Names
CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6
Full Name
Cytochrome P450 family 2 subfamily B member 6
Introduction
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Applications
Resistant to reprogramming by tumor-secreted signals
Reference
Griffiths, L et al. "The macrophage - a novel system to deliver gene therapy to pathological hypoxia." Gene therapy vol. 7,3 (2000): 255-62. doi:10.1038/sj.gt.3301058
Datasheet