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CD73 gRNA Lentiviral Particle for Macrophage Engineering (MTS-0124-LX27)

Datasheet

Overview

Description

CD73 participated in serveral macrophage related functions, including preventing cancer cells from evading immune clearance. The ready-to-use CD73 gRNA Lentiviral Particle is packaged using 3rd generation of lentiviral packaging system, which is a research tool for macrophage cell engineering in vivo and in vitro.

Product Type

Virus Particles

Application Scenario

For in vivo and in vitro macrophage engineering

Target Specification

Engineering Approach

Target KO gRNA Contruction Lentivirus

Species

Human

Target

CD73 gRNA

Alternative Names

NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA

Full Name

5'-nucleotidase ecto

Introduction

The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.

UniprotID

P21589

GeneID

4907

Applications

Prevent cancer cells from evading immune clearance

Reference

Brom, Victoria C et al. "The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies." Frontiers in immunology vol. 13 837645. 28 Mar. 2022, doi:10.3389/fimmu.2022.837645

Product Specification

Packaging System

Lentivirus

Titer

>1E8 TU/mL

Size

200uL; 1mL

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Stored at -80°C for long term.

Handling Notes

Avoid multiple freeze/thaw cycles.

Restriction

RUO

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.