Catalase Lentiviral Particle for Macrophage Engineering (MTS-0124-LX30)

Engineering Approach

Target KO gRNA Contruction Lentivirus

Species

Human

Target

Catalase

Alternative Names

Catalase; CAT

Full Name

Catalase

Introduction

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.

UniprotID

GeneID

Applications

Carry nanozymes to the brain

Reference

Batrakova, Elena V et al. "A macrophage-nanozyme delivery system for Parkinson's disease." Bioconjugate chemistry vol. 18,5 (2007): 1498-506. doi:10.1021/bc700184b

Packaging System

Lentivirus

Titer

>1E8 TU/mL

Size

200uL; 1mL

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Stored at -80°C for long term.

Handling Notes

Avoid multiple freeze/thaw cycles.

Restriction

RUO