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MacroCargo™ Mouse J774 with Neurturin (Transfection System, GenePORTER 3000) (MTS-1122-YF212)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse J774 carried with Neurturin by Transfection System-GenePORTER 3000. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

J774

Cell Type

Cell Line

Cell Species

Mouse

Cell Background

Mouse mononuclear macrophages J774A.1 is a cell line isolated in 1968 from the ascites of an adult, female mouse with reticulum cell sarcoma. This cell line can be used in immunology research.

Cargo Properties

Cargo Type

Protein

Specific Cargo

Neurturin

Cargo Common Name

NRTN

Cargo Alternative Names

NTN

Cargo Full Name

Neurturin

Introduction

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease.

UniprotID

Q99748

GeneID

4902

Cargo Delivery System Type

Transfection System

Cargo Delivery Approach

GenePORTER 3000

Product Properties

Applications

Provide significant neuronal protection in Parkinson's disease

References

Zhao, Yuling et al. "GDNF-transfected macrophages produce potent neuroprotective effects in Parkinson's disease mouse model." PloS one vol. 9,9 e106867. 17 Sep. 2014, doi:10.1371/journal.pone.0106867

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only