As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Macrophages (BMDM) carried with Anti-CSF-1 antibody by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.
Cell Name
Bone Marrow-derived Macrophages (BMDM)
Cell Type
Primary Cell
Cell Species
Mouse
Cell Background
The broad use of transgenic and gene-targeted mice has established bone marrow-derived macrophages (BMDM) as important mammalian host cells for investigation of the macrophages biology.
Cargo Properties
Cargo Type
Checkpoint antibody
Specific Cargo
Anti-CSF-1 antibody
Target Common Name
CSF1
Target Alternative Names
MCSF; CSF-1
Target Full Name
colony stimulating factor 1
Introduction
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants.
Enhance the antitumor effects of immunotherapy; Inhibite TAM differentiation into an M2 phenotype
References
Marin-Acevedo, Julian A., ErinMarie O. Kimbrough, and Yanyan Lou. "Next generation of immune checkpoint inhibitors and beyond." Journal of hematology & oncology 14 (2021): 1-29. Distributed under Open Access license CC BY 4.0, without modification.
Mycoplasma Testing
Negative
Sterility Testing
Negative
Shipping
Dry ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance. Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line. Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.