MacroCargo™ Mouse Bone Marrow-derived Macrophages (BMDM) with Anti-B7-H3 antibody (Viral System, Lentivirus) (MTS-1222-YF127)

Cargo Type

Checkpoint antibody

Specific Cargo

Anti-B7-H3 antibody

Target Common Name

CD276

Target Alternative Names

B7H3; B7-H3; B7RP-2; 4Ig-B7-H3

Target Full Name

CD276 molecule

Introduction

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniprotID

GeneID

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Applications

Enhance the immune system against cancer

References

Marin-Acevedo, Julian A et al. "Next generation of immune checkpoint inhibitors and beyond." Journal of hematology & oncology vol. 14,1 45. 19 Mar. 2021, doi:10.1186/s13045-021-01056-8

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only