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MacroCargo™ Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) with GITR-L gRNA (Viral System, Lentivirus) (MTS-1122-YF388)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) carried with GITR-L gRNA by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs)

Cell Type

Primary Cell

Cell Species

Mouse

Cell Background

High-dose chemotherapy followed by adjuvant autologous hematopoietic stem/progenitor cell (HSPC) transplantation has been tested for the treatment of hematological and solid tumors and can be regarded as a clinical option for certain types of cancer. Scientists have highlighted the important contribution of bone marrow (BM)-derived myeloid cells to tumor angiogenesis.

Cargo Properties

Cargo Type

CRISPR KO

Specific Cargo

GITR-L gRNA

Target Common Name

TNFSF18

Target Alternative Names

TL6; AITRL; GITRL; TNLG2A; hGITRL

Target Full Name

TNF superfamily member 18

Introduction

TL6; AITRL; GITRL; TNLG2A; hGITRL

UniprotID

Q9UNG2

GeneID

8995

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Product Properties

Applications

Induce anti-tumor macrophage phenotypes

References

Brom, Victoria C et al. "The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies." Frontiers in immunology vol. 13 837645. 28 Mar. 2022, doi:10.3389/fimmu.2022.837645

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only