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MacroCargo™ Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) with FPN1 (Viral System, Lentivirus, Fe3O4-nanoparticles) (MTS-1122-YF121)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) carried with FPN1 by Viral System-Lentivirus, Fe3O4-nanoparticles. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs)

Cell Type

Primary Cell

Cell Species

Mouse

Cell Background

High-dose chemotherapy followed by adjuvant autologous hematopoietic stem/progenitor cell (HSPC) transplantation has been tested for the treatment of hematological and solid tumors and can be regarded as a clinical option for certain types of cancer. Scientists have highlighted the important contribution of bone marrow (BM)-derived myeloid cells to tumor angiogenesis.

Cargo Properties

Cargo Type

Protein

Specific Cargo

FPN1

Cargo Common Name

SLC40A1

Cargo Alternative Names

FPN; FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3

Cargo Full Name

Solute carrier family 40 member 1

Introduction

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).

UniprotID

Q9NP59

GeneID

30061

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus, Fe3O4-nanoparticles

Product Properties

Applications

Induce macrophage polarization into the M1 phenotype; Inhibits tumor growth

References

Wu, Cong et al. "Macrophage-Mediated Delivery of Fe3O4-Nanoparticles: A Generalized Strategy to Deliver Iron to Tumor Microenvironment." Current drug delivery vol. 19,9 (2022): 928-939. doi:10.2174/1567201819666220426085450

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only