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MacroCargo™ Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) with Chemo drugs (Nanoparticle System, Silica-based nanoparticles) (MTS-1122-YF113)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) carried with Chemo drugs by Nanoparticle System-Silica-based nanoparticles. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs)

Cell Type

Primary Cell

Cell Species

Mouse

Cell Background

High-dose chemotherapy followed by adjuvant autologous hematopoietic stem/progenitor cell (HSPC) transplantation has been tested for the treatment of hematological and solid tumors and can be regarded as a clinical option for certain types of cancer. Scientists have highlighted the important contribution of bone marrow (BM)-derived myeloid cells to tumor angiogenesis.

Cargo Properties

Cargo Type

Chemo drugs

Specific Cargo

Chemo drugs

Introduction

To be determined according to specific requirements

Cargo Delivery System Type

Nanoparticle System

Cargo Delivery Approach

Silica-based nanoparticles

Nanoparticle Component

A drug-silica complex filling and a solid silica sheath

Product Properties

Applications

Enhance chemotherapeutic drugs delivery to tumor; Reduce side effects

References

Zhang, Weizhong et al. "Nanoparticle-Laden Macrophages for Tumor-Tropic Drug Delivery." Advanced materials (Deerfield Beach, Fla.)vol. 34,6 (2022): e2109925. doi:10.1002/adma.202109925

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only