Online Inquiry

MacroCargo™ Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) with CD40 (Viral System, Lentivirus) (MTS-1122-YF394)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) carried with CD40 by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs)

Cell Type

Primary Cell

Cell Species

Mouse

Cell Background

High-dose chemotherapy followed by adjuvant autologous hematopoietic stem/progenitor cell (HSPC) transplantation has been tested for the treatment of hematological and solid tumors and can be regarded as a clinical option for certain types of cancer. Scientists have highlighted the important contribution of bone marrow (BM)-derived myeloid cells to tumor angiogenesis.

Cargo Properties

Cargo Type

Protein

Specific Cargo

CD40

Cargo Common Name

CD40

Cargo Alternative Names

p50; Bp50; CDW40; TNFRSF5

Cargo Full Name

CD40 molecule

Introduction

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

UniprotID

P29965

GeneID

959

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Product Properties

Applications

Promote bactericidal and tumoricidal activity of macrophages

References

Brom, Victoria C et al. "The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies." Frontiers in immunology vol. 13 837645. 28 Mar. 2022, doi:10.3389/fimmu.2022.837645

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only