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MacroCargo™ Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) with Anti-Tie-2 antibody (Viral System, Lentivirus) (MTS-1122-YF402)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Mouse Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs) carried with Anti-Tie-2 antibody by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

Bone Marrow-derived Hematopoietic Stem/Progenitor Cells (HSPCs)

Cell Type

Primary Cell

Cell Species

Mouse

Cell Background

High-dose chemotherapy followed by adjuvant autologous hematopoietic stem/progenitor cell (HSPC) transplantation has been tested for the treatment of hematological and solid tumors and can be regarded as a clinical option for certain types of cancer. Scientists have highlighted the important contribution of bone marrow (BM)-derived myeloid cells to tumor angiogenesis.

Cargo Properties

Cargo Type

Checkpoint antibody

Specific Cargo

Anti-Tie-2 antibody

Target Common Name

TEK

Target Alternative Names

TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B

Target Full Name

TEK receptor tyrosine kinase

Introduction

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

UniprotID

Q02763

GeneID

7010

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Product Properties

Applications

Improve macrophages persist in solid tumors

References

DeNardo, David G, and Brian Ruffell. "Macrophages as regulators of tumour immunity and immunotherapy." Nature reviews. Immunology vol. 19,6 (2019): 369-382. doi:10.1038/s41577-019-0127-6

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only