Specific Cargo
pDNA encoding IL-21
Cargo Alternative Names
Za11; IL-21; CVID11
Cargo Full Name
Interleukin 21
Introduction
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Cargo Delivery System Type
Nanoparticle System
Cargo Delivery Approach
Magnetic cationic liposomes
Nanoparticle Component
DOTAP, DSPC, cholesterol, iron oxide (II, III).
Datasheet