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MacroCargo™ Human THP-1 with Anti-CEACAM5 antibody (Viral System, Lentivirus) (MTS-1222-YF421)

Cell Properties

Product Overview
As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human THP-1 carried with Anti-CEACAM5 antibody by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.
Cell Name
THP-1
Cell Type
Cell Line
Cell Species
Human
Cell Background
THP-1 is a monocyte isolated from peripheral blood from an acute monocytic leukemia patient. This cell line can be used in immune system disorder research, immunology research, and toxicology research.

Cargo Properties

Cargo Type
Checkpoint antibody
Specific Cargo
Anti-CEACAM5 antibody
Target Common Name
CEACAM5
Target Alternative Names
CEA; CD66e
Target Full Name
CEA cell adhesion molecule 5
Introduction
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
UniprotID
GeneID
Cargo Delivery System Type
Viral System
Cargo Delivery Approach
Lentivirus

Product Properties

Applications
Reduce inhibition of T cell activation
References
Marin-Acevedo, Julian A et al. "Next generation of immune checkpoint inhibitors and beyond." Journal of hematology & oncology vol. 14,1 45. 19 Mar. 2021, doi:10.1186/s13045-021-01056-8
Mycoplasma Testing
Negative
Sterility Testing
Negative
Shipping
Dry ice
Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.
Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.
Restriction
Research use only

For Research Use Only. Do Not Use in Food Manufacturing or Medical Procedures (Diagnostics or Therapeutics). Do Not Use in Humans.

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