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MacroCargo™ Human PBMC-derived Monocytes with Chemo drugs (Nanoparticle System, Silica-based nanoparticles) (MTS-1222-YF500)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human PBMC-derived Monocytes carried with Chemo drugs by Nanoparticle System-Silica-based nanoparticles. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

PBMC-derived Monocytes

Cell Type

Primary Cell

Cell Species

Human

Cell Background

Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulation. Evidence from murine and human studies has suggested that monocytosis can be an indicator of various inflammatory diseases. Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into tissue macrophages or dendritic cells.

Cargo Properties

Cargo Type

Chemo drugs

Specific Cargo

Chemo drugs

Introduction

To be determined according to specific requirements

Cargo Delivery System Type

Nanoparticle System

Cargo Delivery Approach

Silica-based nanoparticles

Nanoparticle Component

A drug-silica complex filling and a solid silica sheath

Product Properties

Applications

Enhance chemotherapeutic drugs delivery to tumor; Reduce side effects

References

Zhang, Weizhong et al. "Nanoparticle-Laden Macrophages for Tumor-Tropic Drug Delivery." Advanced materials (Deerfield Beach, Fla.)vol. 34,6 (2022): e2109925. doi:10.1002/adma.202109925

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only