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MacroCargo™ Human PBMC-derived Macrophages with Soluble transforming growth factor beta receptor II (sTGFbRII) (Viral System, Lentivirus) (MTS-1122-YF9)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human PBMC-derived Macrophages carried with Soluble transforming growth factor beta receptor II (sTGFbRII) by Viral System-Lentivirus. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

PBMC-derived Macrophages

Cell Type

Primary Cell

Cell Species

Human

Cell Background

Macrophages are specialised cells involved in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In addition, they can also present antigens to T cells and initiate inflammation by releasing molecules (known as cytokines) that activate other cells. Furthermore, macrophages are able to cross the biological barriers, penetrate into tumors, and accumulate particularly in hypoxic and poorly vascularized portions of a tumor.

Cargo Properties

Cargo Type

Protein

Specific Cargo

Soluble transforming growth factor beta receptor II (sTGFbRII)

Cargo Common Name

TGFBR2

Cargo Alternative Names

AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; tbetaR-II; TGFbeta-RII

Cargo Full Name

Transforming growth factor beta receptor 2

Introduction

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.

UniprotID

P37173

GeneID

7048

Cargo Delivery System Type

Viral System

Cargo Delivery Approach

Lentivirus

Product Properties

Applications

Promote cytotoxic immune response

References

Moyes, Kara W et al. "Genetically Engineered Macrophages: A Potential Platform for Cancer Immunotherapy." Human gene therapy vol. 28,2 (2017): 200-215. doi:10.1089/hum.2016.060

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only