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MacroCargo™ Human PBMC-derived Macrophages with pDNA encoding IL-17b (Nanoparticle System, Magnetic cationic liposomes) (MTS-1222-YF22)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human PBMC-derived Macrophages carried with pDNA encoding IL-17b by Nanoparticle System-Magnetic cationic liposomes. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

PBMC-derived Macrophages

Cell Type

Primary Cell

Cell Species

Human

Cell Background

Macrophages are specialised cells involved in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In addition, they can also present antigens to T cells and initiate inflammation by releasing molecules (known as cytokines) that activate other cells. Furthermore, macrophages are able to cross the biological barriers, penetrate into tumors, and accumulate particularly in hypoxic and poorly vascularized portions of a tumor.

Cargo Properties

Cargo Type

Cytokine

Specific Cargo

pDNA encoding IL-17b

Cargo Common Name

IL17B

Cargo Alternative Names

NIRF; IL-20; IL-17B; ZCYTO7

Cargo Full Name

Interleukin 17B

Introduction

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants.

UniprotID

Q9UHF5

GeneID

27190

Cargo Delivery System Type

Nanoparticle System

Cargo Delivery Approach

Magnetic cationic liposomes

Nanoparticle Component

DOTAP, DSPC, cholesterol, iron oxide (II, III).

Product Properties

Applications

Improve the delivery of macrophages to tumors and its therapeutic efficacy against inflammatory diseases

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only