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MacroCargo™ Human PBMC-derived Macrophages with Chemo drugs (Nanoparticle System) (MTS-1122-YF21)

Datasheet

Cell Properties

Product Overview

As a therapeutic tool, macrophage cell has a great capacity for delivering cargos because of their intrinsic characteristics. This product is engineered Human PBMC-derived Macrophages carried with Chemo drugs by Nanoparticle System. MacroCargo™ products aim to improve the macrophage function and delivery of specific cargos. We also provide custom macrophage delivery systems based on your specific requirements.

Cell Name

PBMC-derived Macrophages

Cell Type

Primary Cell

Cell Species

Human

Cell Background

Macrophages are specialised cells involved in the detection, phagocytosis and destruction of bacteria and other harmful organisms. In addition, they can also present antigens to T cells and initiate inflammation by releasing molecules (known as cytokines) that activate other cells. Furthermore, macrophages are able to cross the biological barriers, penetrate into tumors, and accumulate particularly in hypoxic and poorly vascularized portions of a tumor.

Cargo Properties

Cargo Type

Chemo drugs

Specific Cargo

Chemo drugs

Introduction

To be determined according to specific requirements

Cargo Delivery System Type

Nanoparticle System

Cargo Delivery Approach

Nanoparticals

Nanoparticle Component

Lipoid E80, phosphatidylethanoloamine, and the hydrolyzed lyso.

Product Properties

Applications

Maintain drug concentrations; Improve drug distribution; Reduce side effects

References

Dou, Huanyu et al. "Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery." Blood vol. 108,8 (2006): 2827-35. doi:10.1182/blood-2006-03-012534

Mycoplasma Testing

Negative

Sterility Testing

Negative

Shipping

Dry ice

Storage

Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C) for long term.

Handling Notes

Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Restriction

Research use only