Engineering Approach
Target KO antibody Contruction Lentivirus
Alternative Names
B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291
Full Name
V-set domain containing T cell activation inhibitor 1
Introduction
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications
Prevent cancer cells from evading immune clearance
Reference
Brom, Victoria C et al. "The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies." Frontiers in immunology vol. 13 837645. 28 Mar. 2022, doi:10.3389/fimmu.2022.837645
Datasheet