Engineering Approach
Checkpoint Antibody Seq Overexpression-Lentivirus
Target
Anti-TIGIT antibody
Alternative Names
VSIG9; VSTM3; WUCAM
Full Name
T cell immunoreceptor with Ig and ITIM domains
Introduction
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Applications
Resistant to reprogramming by tumor-secreted signals
Datasheet