Engineering Approach
Checkpoint Antibody Seq Overexpression-Lentivirus
Target
Anti-BTLA antibody
Alternative Names
BTLA1; CD272
Full Name
B and T lymphocyte associated
Introduction
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis.
Applications
Resistant to reprogramming by tumor-secreted signals